Indications

Potential OPDIVO® (nivolumab) user sitting with his grandchildren beside a lake.
Potential OPDIVO® (nivolumab) user sitting with his grandchildren beside a lake.

Clinical trial results for
previously treated
advanced non-small cell
lung cancer (NSCLC)

For adults with previously treated advanced non-small cell lung cancer (NSCLC)

Actor portrayals.
OPDIVO is not approved for people
younger than 18 years of age.

An FDA-approved immunotherapy that was proven to increase survival for both squamous and non-squamous NSCLC compared to chemotherapy

ADVANCED NON-SQUAMOUS NSCLC

About the clinical trial

In a clinical trial of 582 people with previously treated non-squamous NSCLC that had spread or grown after treatment with platinum-based chemotherapy, 292 people were given OPDIVO and 290 people were given chemotherapy (docetaxel).

Significantly more people given OPDIVO were alive at 1 year compared to chemotherapy

51% of patients given OPDIVO® (nivolumab) for non-squamous NSCLC were alive at 1 year, compared to 39% on chemotherapy.

People given OPDIVO lived longer compared to chemotherapy

At 12 months, half the people given OPDIVO® (nivolumab) for advanced non-squamous NSCLC were alive.
OPDIVO

Half the people were alive

At 9 months, half the people given chemotherapy (docetaxel) for advanced non-squamous NSCLC were alive.
Chemotherapy (docetaxel)

Half the people were alive

In the primary analysis with a follow-up at 1 year, people given OPDIVO had a 27% lower risk of dying than those given chemotherapy.

OPDIVO will not work for everyone. Individual results may vary.

ADVANCED SQUAMOUS NSCLC

About the clinical trial

In a clinical trial of 272 people with squamous NSCLC that had spread or grown after treatment with platinum-based chemotherapy, 135 people were given OPDIVO and 137 people were given chemotherapy (docetaxel).

More people given OPDIVO were alive at 1 year compared to chemotherapy

42% of patients given OPDIVO® (nivolumab) for advanced squamous NSCLC were alive at 1 year, compared to 24% on chemotherapy.

People given OPDIVO lived longer compared to chemotherapy

At 9 months, half of the people given OPDIVO® (nivolumab) for advanced squamous NSCLC were alive.
OPDIVO

Half the people were alive

At 6 months, half of the people given chemotherapy (docetaxel) for advanced squamous NSCLC were alive.
Chemotherapy (docetaxel)

Half the people were alive

In the primary analysis with a follow-up at 1 year, people given OPDIVO had a 41% lower risk of dying than those given chemotherapy.

OPDIVO will not work for everyone. Individual results may vary.

“Both my wife and I cried. I can tell you one thing, that having cancer made me take another look at golf.”


John’s story

John is a husband, father of two, and a passionate golfer. Learn more about his experience with OPDIVO for his previously treated NSCLC.

John, a husband, father, and passionate golfer, shares his experience with OPDIVO® (nivolumab) for previously treated NSCLC.
Hands exploring how OPDIVO® (nivolumab) works and learning how this treatment may help fight cancer.

How treatment works

See how this treatment may help your body fight cancer

OPDIVO® (nivolumab) side effects.

Side effects

View side effects of treatment and learn how to manage them

Nurse monitoring a gentleman's infusion of OPDIVO® (nivolumab) immunotherapy treatment.

Getting an infusion

See your recommended treatment plan and what to expect from an infusion

For adults with previously treated advanced non-small cell lung cancer

OPDIVO® (nivolumab) is a prescription medicine used to treat adults with a type of advanced stage lung cancer (called non-small cell lung cancer) that has spread or grown and you have tried chemotherapy that contains platinum, and it did not work or is no longer working. If your tumor has an abnormal EGFR or ALK gene, you should have also tried an FDA-approved therapy for tumors with these abnormal genes, and it did not work or is no longer working.

It is not known if OPDIVO is safe and effective in children younger than 12 years of age with melanoma or MSI-H or dMMR metastatic colorectal cancer.

It is not known if OPDIVO is safe and effective in children for the treatment of any other cancers.




1506-US-2400468 09/24