Getting an infusion for
previously treated colorectal
cancer (MSI-H/dMMR)
For adults and children 12 years of age and older whose MSI-H/dMMR colorectal cancer (CRC) has spread to other parts of the body (metastatic) and who have tried treatment with a fluoropyrimidine, oxaliplatin, and irinotecan, and it did not work or is no longer working
Actor portrayals.
OPDIVO + YERVOY is not approved
for people younger than 12 years of age.
This treatment uses two medications: OPDIVO and YERVOY. They are given on the same day as separate intravenous (IV) infusions, meaning that they are delivered into your vein.
This is what your treatment plan may look like
Talk to your doctor about your plan and ask any questions you may have before starting treatment. Only your doctor can make specific recommendations about your treatment.
EVERY 3 WEEKS
Your dose of OPDIVO may vary depending on how often you receive treatment.
OPTION 1 – A LOWER DOSE EVERY 2 WEEKS
More regularly scheduled time with your healthcare team with less time in between appointments
Your treatment will continue as long as it is working, and side effects are manageable.
OPTION 2 – A HIGHER DOSE EVERY 4 WEEKS
Your treatment will continue as long as it is working, and side effects are manageable.
For children 12 years and older weighing less than 88 lbs, dosing will continue to be determined by your doctor based on weight. In phase 1, OPDIVO and YERVOY will be given every 3 weeks and in phase 2, OPDIVO will be given every 2 weeks.
To make it easier for your treatment to fit into your routine, try to schedule your appointments for the same day and time each week. You can also designate that time to talk with your healthcare team to let them know how you’re feeling and to ask questions.
Wear clothes and shoes that make you feel comfortable so it’s easier to relax. Think about bringing a light blanket or a travel pillow for even more comfort.
Help pass the time at your treatment by bringing a book, magazine, tablet, or using your phone. (And don’t forget to bring your chargers.)
It’s important to pay close attention to how you feel during and after treatments and let your healthcare team know how you feel. During treatment, your healthcare team will also check you for side effects and may treat you with additional medications to help relieve them. Your healthcare team may also need to delay or completely stop your treatment if you have severe side effects.
We hope that the information on this page is helpful but be sure to communicate with your healthcare team because they are your best source of information. Talk to your healthcare team about anything you may be experiencing during your treatment. See below for possible side effects.
Learn more about the complimentary OPDIVO with You support program
Explore resources to help you along your treatment journey
Explore findings from clinical trials with OPDIVO and OPDIVO-based combinations
