Clinical trial results for
previously treated
advanced liver cancer
For adults with a type of liver cancer called hepatocellular carcinoma when your liver cancer cannot be removed by surgery or has spread, and you have received prior treatment with sorafenib
Actor portrayals.
In a clinical trial, the overall response rate and duration of response to OPDIVO + YERVOY were looked at in 49 people with hepatocellular carcinoma whose cancer spread or grew after treatment with sorafenib or who could not tolerate sorafenib therapy.
Tumors disappeared completely (complete response)
Tumors shrank
(partial response)
Tumors shrank or disappeared completely (overall response)
Half of the people who responded to OPDIVO + YERVOY continued to respond for at least 17.5 months, also known as median duration of response. The shortest response lasted 4.6 months and the longest response lasted 30.5 months.
88% of people who responded had a response for six months or longer.
56% of people who responded had a response for 1 year or longer.
31% of people who responded had a response for 2 years or longer.
Words to know
Overall response rate is the percentage of patients who responded to treatment. These patients saw their tumors either shrink or disappear completely.
Partial response is when a tumor reacts to treatment and shrinks.
Complete response is when a tumor reacts to treatment and disappears completely. This is the disappearance of any measurable tumors in response to treatment. This does not mean the cancer has been cured.
Duration of response is the measure of how long these responses lasted. The median duration of response is the length of time half of the patients were still responding to treatment.
OPDIVO + YERVOY will not work for everyone. Individual results may vary.
See your recommended treatment plan and what to expect from an infusion
For adults whose liver cancer (hepatocellular carcinoma) has spread or grown after treatment with sorafenib
OPDIVO® (nivolumab) is a prescription medicine used in combination with YERVOY® (ipilimumab) to treat adults with a type of liver cancer called hepatocellular carcinoma (HCC) when your liver cancer cannot be removed by surgery or has spread, and you have received prior treatment with sorafenib.
It is not known if OPDIVO is safe and effective in children younger than 12 years of age with melanoma or MSI-H or dMMR metastatic colorectal cancer.
It is not known if OPDIVO is safe and effective in children for the treatment of any other cancers.
OPDIVO (10 mg/mL) and YERVOY (5 mg/mL) are injections for intravenous (IV) use.
