Clinical trial results for
advanced melanoma
For adults and children 12 years of age and older with melanoma that has spread or cannot be removed by surgery (advanced melanoma)
Actor portrayals.
OPDIVO is not approved for people
younger than 12 years of age.
An FDA-approved immunotherapy that helped people live longer compared to YERVOY alone
About the clinical trial
In a clinical trial of 945 people with previously untreated advanced melanoma, 314 people were given OPDIVO + YERVOY, 316 people were given OPDIVO alone, and 315 people were given YERVOY alone. While your doctor may test you for the BRAF biomarker to help you consider your treatment options, OPDIVO is FDA approved to treat advanced melanoma regardless of your test results.
More people given OPDIVO were alive compared to YERVOY alone at the primary analysis with a minimum follow-up of 28 months
In the clinical trial, people given OPDIVO had a 37% lower risk of dying than those given YERVOY alone.
People given OPDIVO lived longer without their cancer spreading, growing, or getting worse compared to YERVOY alone at the primary analysis with a minimum follow-up of 9 months
OPDIVO
Half the people went without their cancer spreading, growing, or getting worse
YERVOY alone
Half the people went without their cancer spreading, growing, or getting worse
In the clinical trial, people given OPDIVO had a 43% lower risk of their cancer spreading, growing, or getting worse than those given YERVOY alone.
More people given OPDIVO saw their tumors shrink or disappear completely compared to YERVOY alone at the primary analysis with a minimum follow-up of 9 months
OPDIVO |
YERVOY alone |
Tumors disappeared completely (complete response)
Tumors shrank (partial response)
Tumors shrank or disappeared completely (overall response)
Words to know
Overall response rate is the percentage of patients who responded to treatment. These patients saw their tumors either shrink or disappear completely.
Partial response is when a tumor reacts to treatment and shrinks.
Complete response is when a tumor reacts to treatment and disappears completely. This is the disappearance of any measurable tumors in response to treatment. This does not mean the cancer has been cured.
OPDIVO will not work for everyone. Individual results may vary.
Getting an infusion
See your recommended treatment plan and what to expect from an infusion
For adults and children 12 years of age and older with advanced melanoma
OPDIVO® (nivolumab) is a prescription medicine used to treat adults and children 12 years of age and older with a type of skin cancer called melanoma that has spread or cannot be removed by surgery (advanced melanoma).
It is not known if OPDIVO is safe and effective in children younger than 12 years of age with melanoma or MSI-H or dMMR metastatic colorectal cancer.
It is not known if OPDIVO is safe and effective in children for the treatment of any other cancers.