What you should know
about side effects

Although not every person may experience them, side effects are still possible with OPDIVO and OPDIVO-based combinations. Learn more about the most common side effects, potential side effects, and how to manage these side effects as well.

↓ Most common side effects

↓ Potential side effects

↓ Side effects tracker

OPDIVO or OPDIVO + YERVOY can cause serious side effects. OPDIVO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. You may have more than one of these problems at the same time. Some of these problems may happen more often when OPDIVO is used in combination with another therapy.

Most common side effects

It’s important to remember that these are not all of the possible side effects of OPDIVO or OPDIVO-based combinations. That’s why you need to report any discomfort or change in the way you are feeling to your healthcare team, even if your symptoms are not listed below. Some of the side effects may be life-threatening and may need your doctor's immediate attention.

These are not all the possible side effects. Talk to your healthcare team or pharmacist for more information. You are encouraged to report side effects of prescription drugs to the FDA. Call 1-800-FDA-1088.

OPDIVO alone

OPDIVO when used in combination with YERVOY

OPDIVO when used in combination with YERVOY and chemotherapy

OPDIVO when used in combination with cabozantinib

OPDIVO when used in combination with chemotherapy

OPDIVO when used in combination with fluoropyrimidine- and platinum-containing chemotherapy

Complications, including graft-versus-host disease (GVHD), of bone marrow (stem cell) transplant that uses donor stem cells (allogeneic) may occur. These complications can be severe and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with OPDIVO or YERVOY. Your healthcare provider will monitor you for these complications.

Potential side effects

Lung problems

New or worsening cough
Shortness of breath
Chest pain

Intestinal problems

Diarrhea (loose stools) or more frequent bowel movements than usual
Stools that are black, tarry, sticky, or have blood or mucus
Severe stomach-area (abdominal) pain or tenderness

Liver problems

Yellowing of your skin or the whites of your eyes
Severe nausea or vomiting
Pain on the right side of your stomach area (abdomen)
Dark urine (tea colored)
Bleeding or bruising more easily than normal

Hormone gland problems

Headaches that will not go away or unusual headaches
Eye sensitivity to light
Eye problems
Rapid heartbeat
Increased sweating
Extreme tiredness
Weight gain or weight loss
Feeling more hungry or thirsty than usual
Urinating more often than usual
Hair loss
Feeling cold
Constipation
Your voice gets deeper
Dizziness or fainting
Changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems

Decrease in your amount of urine
Blood in your urine
Swelling in your ankles
Loss of appetite

Skin problems

Rash
Itching
Skin blistering or peeling
Painful sores or ulcers in the mouth or nose, throat, or genital area

Eye problems

Blurry vision, double vision, or other vision problems
Eye pain or redness

Problems in other organs

Chest pain, irregular heartbeat, shortness of breath, swelling of ankles
Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
Persistent or severe muscle pain or weakness, muscle cramps
Low red blood cells, bruising

Severe infusion reactions

Tell your doctor or nurse right away if you get these symptoms during an infusion of OPDIVO:

Chills or shaking
Itching or rash
Flushing
Shortness of breath or wheezing
Dizziness
Feel like passing out
Fever
Back or neck pain

Tracking potential side effects

When taking OPDIVO or an OPDIVO-based combination, it’s important to play an active role in talking with your healthcare team, as many signs and symptoms of side effects can only be noticed by you.

Make sure to pay attention to how you are feeling and be especially aware of any new discomfort that appears unexpectedly or any condition that suddenly gets worse.

If you notice a change in the way you are feeling—even if it seems small or irrelevant—contact your healthcare team immediately, and don’t try to treat possible side effects yourself.

↓ Download the OPDIVO + YERVOY side effect tracker